City of Lancaster, Ohio



Clomiphene is a non-steroidal fertility medicine. It causes the pituitary gland to release hormones needed to stimulate ovulation (the release of an egg from the ovary). Clomiphene is used to cause ovulation in women with certain medical conditions (such as polycystic ovary syndrome) that prevent naturally occurring ovulation. Clomiphene may also be used for purposes not listed in this medication guide.

Dose of clomiphene citrate in male infertility with a sperm concentration at or above 5 × IU/l). The most common side effects on male patients were anorexia, loss of libido, hot flushes, headache, nausea, and tachycardia (6). Clomiphene citrate administration reduces sperm motility [estimated percent motile as a percentage (number of sperm motiling per unit time) between 24 and 48 hours (6)], increasing plasma gonadotropin levels [estimated index = number of serum gonadotropin/mean plasma levels the active form gonadotropin, and is in the normal range of reference (7)]. Side effects, which become worse after clomiphene, include depression and irritability [depression symptoms], impotence [impotence and increased libido (7). Clomiphene citrate does not interfere negatively with fertility (13). An effective and inexpensive dose protocol for a long-term male contraceptive has not been elucidated. The current data, however, suggest that the contraceptive benefits of clomiphene are only possible in patient with a low sperm count and poor motility, especially in this patient population; otherwise, clomiphene could cause significant clinical side effects. This is consistent with the observation that a high concentration of clomiphene in clinical studies was asso